Principal Investigator
Andreas Matouschek, PhD

Professor, Molecular Biosciences

Postdoctoral Fellows
Amit Kumar Singh Gautam, PhD

Ph.D. in Life science from Homi Bhabha Nation Institute, Mumbai

M.S. in Biotechnology

agautam @

-What I am currently doing: I am trying to understand what sequence properties proteasome likes when it comes to initiate degradation from the termini as well from an internal region in the protein.

-Why I enjoy doing science: Science is a way of thinking much more than it is a body of knowledge -Carl Sagan. I consider myself lucky to be in a profession that is full of challenges and surprises.
-When not in lab physically and mentally: Spend time with my daughter, watching something on Netflix, enjoying good food or visiting a new place. 

Kazunobu Takahashi, PhD

Ph.D. in Department of Physics, University of Tokyo

kznb.takahashi @

My research philosophy is to understand biological phenomena quantitatively. By shedding light on proteasome activity using fluorescent protein sensors, I am trying to unveil the mechanisms of cellular processes such as aging.

Caroline Davis​, PhD

PhD in Cell and Molecular Biology, The University of Texas at Austin, 2020

B.S. in Cell and Molecular Biology, Florida State University, 2014

thecarolinedavis @

I am characterizing how arrangement of ubiquitin chain and initiation region affect degradation. In other words, how does the geometry of the degradation targeting signal modulate substrate selection by the proteasome? When not in lab you can find me hiking with my dog (Derek Shepherd), drinking cider, or playing ultimate. Find me on science twitter!

Research Scientists & Staff
Jacob Anguiano.jpg

Jacob Anguiano

Undergraduate Research Assistant 

Hello my name is Jacob Dylan Anguiano. I am in my second year here at the University of Texas at Austin. I am currently studying Advertising at the Stan Richards School. I really enjoy the lab because it strays from what I am studying and really allows me to be diverse in my learning. I am glad to be here and look forward to a great semester and advancing year.

Graduate Students

Logan Spaller (Biochem)

B.S. in Chemistry, University of North Carolina at Chapel Hill, 2017

lspaller @

I graduated from the University of North Carolina at Chapel Hill with my B.S. in Chemistry and joined the Matouschek Lab in 2018 in pursuit of my PhD in the Institute for Cellular and Molecular Biology at the University of Texas at Austin. I study the ubiquitin proteasome system, which helps control cellular protein levels by degrading them. There are two primary components that determine if a substrate will be targeted to the proteasome: ubiquitination and a disordered initiation region. My project uses in vivo methods to study the interactions of these two targeting factors to better understand how the proteasome controls substrate specificity. In my free time I like to travel and experience new places and cultures. I also enjoy scuba diving, surfing, swimming, and playing soccer.

John Cooper (Biochem)

B.S. Biochemistry at University of Michigan

jpcoope @

I'm probing the relationship between proteasome activity and the lifespan and cell cycle of individual S. Cerevisiae cells. Toward this end, I'm working on developing microfluidic devices and image analysis pipelines that can isolate and track large populations of cells throughout their lifetime. I love eating and cooking great food, going to shows, and skating around Austin. 

Undergraduate Students

Haemin Chong

B.S.A. in Biology, University of Texas at Austin (Expected 2021)

haemin.chong @

I am an undergraduate student at UT majoring in Biology and minoring in Philosophy and Russian. I am looking forward to learning more about the role of geometry in the ubiquitin-proteasome system while assisting Caroline Davis with her project. One day, I would like to apply the skills gained from this lab to my own project. In my free time I like to listen to podcasts, watch movies, and try new food. 

Tyler Guthrie

B.S. in Biochemistry, University of Texas at Austin (Expected 2021)

tguthrie8398 @

I am an undergraduate Biochemistry major at UT Austin. I am assisting Logan Spaller in studying the ubiquitin proteasome systems, specifically how Cdc48 works in vivo to promote protein degradation. After receiving my bachelor's at UT I am planning on continuing into graduate school to pursue a Ph.D. in Biochemistry. In my free time, I enjoy watching new movies /shows, exploring new places to eat, and spending time with friends.